PDB entry 4ty8

View 4ty8 on RCSB PDB site
Description: An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Class: transferase/transferase inhibitor
Keywords: NS5B, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-07-08, released 2015-05-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polyprotein
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ty8a_
  • Chain 'B':
    Compound: Polyprotein
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0PY27 (0-End)
      • engineered mutation (549)
    Domains in SCOPe 2.07: d4ty8b_
  • Chain 'C':
    Compound: Polyprotein
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ty8c_
  • Chain 'D':
    Compound: Polyprotein
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ty8d_
  • Heterogens: 3AV

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ty8A (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhslsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ty8A (A:)
smsytwtgalitpcaaeesklpnsllrhhnmvyattsrsaglrqkkvtfdrlqvlddhyr
dvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkd
lledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvmgss
ygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapear
qaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqd
ctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclr
klgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpisgwfvagysgg
diyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ty8B (B:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgmfvagysggdiyhslsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ty8B (B:)
smsytwtgalitpcaaeesklpnsllrhhnmvyattsrsaglrqkkvtfdrlqvlddhyr
dvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkd
lledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvmgss
ygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapear
qaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqd
ctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclr
klgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasgmfvagy
sggdiyh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ty8C (C:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhslsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ty8C (C:)
smsytwtgalitpcaaeesklpnsllrhhnmvyattsrsaglrqkkvtfdrlqvlddhyr
dvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkd
lledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvmgss
ygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapear
qaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqd
ctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclr
klgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipsgwfvagysg
gdiyh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ty8D (D:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhslsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ty8D (D:)
smsytwtgalitpcaaeesklpnsllrhhnmvyattsrsaglrqkkvtfdrlqvlddhyr
dvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkd
lledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvmgss
ygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapear
qaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqd
ctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclr
klgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipasgwfvagys
ggdiyh