PDB entry 4tr9

View 4tr9 on RCSB PDB site
Description: Ternary co-crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP and a small molecule inhibitor
Class: Lyase/Lyase Inhibitor
Keywords: Lyase-Lyase Inhibitor complex
Deposited on 2014-06-15, released 2015-08-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-09-02, with a file datestamp of 2015-08-28.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-bisphosphate aldolase
    Species: Plasmodium falciparum [TaxId:36329]
    Gene: PF14_0425
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4tr9a_
  • Chain 'B':
    Compound: Fructose-bisphosphate aldolase
    Species: Plasmodium falciparum [TaxId:36329]
    Gene: PF14_0425
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4tr9b_
  • Chain 'C':
    Compound: Fructose-bisphosphate aldolase
    Species: Plasmodium falciparum [TaxId:36329]
    Gene: PF14_0425
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4tr9c_
  • Chain 'D':
    Compound: Fructose-bisphosphate aldolase
    Species: Plasmodium falciparum [TaxId:36329]
    Gene: PF14_0425
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4tr9d_
  • Chain 'E':
    Compound: ala-ala-ser-leu-tyr-glu-lys-lys-ala-ala
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-9)
  • Chain 'G':
    Compound: ala-ala-ala-ser-leu-tyr-glu-lys-lys-ala-ala
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-10)
  • Chain 'H':
    Compound: asp-trp-asn
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-2)
  • Chain 'I':
    Compound: asp-trp-asn
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-2)
  • Chain 'J':
    Compound: asp-trp-asn
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-2)
  • Chain 'K':
    Compound: asp-trp-asn
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Database cross-references and differences (RAF-indexed):
    • PDB 4TR9 (0-2)
  • Heterogens: 38D, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tr9A (A:)
mahcteymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentie
nrasyrdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvn
ipctdeekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglar
yasicqqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnm
vtagyectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgph
pwaltfsygralqasvlntwqgkkenvakarevllqraeanslatygkykggaggenaga
slyekkyvy

    Sequence, based on observed residues (ATOM records): (download) 
    >4tr9A (A:)
eymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentienrasy
rdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvnipctd
eekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglaryasic
qqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnmvtagy
ectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgphpwalt
fsygralqasvlntwqgkkenvakarevllqraeanslatygkykgg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4tr9B (B:)
mahcteymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentie
nrasyrdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvn
ipctdeekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglar
yasicqqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnm
vtagyectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgph
pwaltfsygralqasvlntwqgkkenvakarevllqraeanslatygkykggaggenaga
slyekkyvy

    Sequence, based on observed residues (ATOM records): (download) 
    >4tr9B (B:)
eymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentienrasy
rdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvnipctd
eekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglaryasic
qqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnmvtagy
ectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgphpwalt
fsygralqasvlntwqgkkenvakarevllqraeanslatygkykgg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4tr9C (C:)
mahcteymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentie
nrasyrdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvn
ipctdeekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglar
yasicqqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnm
vtagyectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgph
pwaltfsygralqasvlntwqgkkenvakarevllqraeanslatygkykggaggenaga
slyekkyvy

    Sequence, based on observed residues (ATOM records): (download) 
    >4tr9C (C:)
eymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentienrasy
rdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvnipctd
eekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglaryasic
qqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnmvtagy
ectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgphpwalt
fsygralqasvlntwqgkkenvakarevllqraeanslatygkykgg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4tr9D (D:)
mahcteymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentie
nrasyrdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvn
ipctdeekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglar
yasicqqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnm
vtagyectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgph
pwaltfsygralqasvlntwqgkkenvakarevllqraeanslatygkykggaggenaga
slyekkyvy

    Sequence, based on observed residues (ATOM records): (download) 
    >4tr9D (D:)
eymnapkklpadvaeelattaqklvqagkgilaadestqtikkrfdniklentienrasy
rdllfgtkglgkfisgailfeetlfqkneagvpmvnllhneniipgikvdkglvnipctd
eekstqgldglaerckeyykagarfakwrtvlvidtakgkptdlsihetawglaryasic
qqnrlvpivepeiladgphsievcavvtqkvlscvfkalqengvllegallkpnmvtagy
ectaktttqdvgfltvrtlrrtvppalpgvvflsggqseeeasvnlnsinalgphpwalt
fsygralqasvlntwqgkkenvakarevllqraeanslatygkykgg

  • Chain 'E':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.