PDB entry 4qtb

View 4qtb on RCSB PDB site
Description: Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket
Class: Transferase/transferase inhibitor
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE, kinase, MAPK, signalling, inhibitor, allosteric, Structural Genomics Consortium (SGC), Transferase-transferase inhibitor complex
Deposited on 2014-07-07, released 2014-07-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.148
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERK1, MAPK3, PRKM3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERK1, MAPK3, PRKM3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4qtbb_
  • Heterogens: EDO, DMS, CL, SO4, 38Z, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qtbB (B:)
smaaaaaqgggggeprrtegvgpgvpgevemvkgqpfdvgprytqlqyigegaygmvssa
ydhvrktrvaikkispfehqtycqrtlreiqillrfrhenvigirdilrastleamrdvy
ivqdlmetdlykllksqqlsndhicyflyqilrglkyihsanvlhrdlkpsnllinttcd
lkicdfglariadpehdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaeml
snrpifpgkhyldqlnhilgilgspsqedlnciinmkarnylqslpsktkvawaklfpks
dskaldlldrmltfnpnkritveealahpyleqyydptdepvaeepftfamelddlpker
lkelifqetarfqpgvleap

    Sequence, based on observed residues (ATOM records): (download) 
    >4qtbB (B:)
evemvkgqpfdvgprytqlqyigegaygmvssaydhvrktrvaikkispfehqtycqrtl
reiqillrfrhenvigirdilrastleamrdvyivqdlmetdlykllksqqlsndhicyf
lyqilrglkyihsanvlhrdlkpsnllinttcdlkicdfglariadpehdhtgflteyva
trwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsq
edlnciinmkarnylqslpsktkvawaklfpksdskaldlldrmltfnpnkritveeala
hpyleqyydptdepvaeepftfamelddlpkerlkelifqetarfqpg