PDB entry 4obc

View 4obc on RCSB PDB site
Description: Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238)
Class: Viral Protein, transferase
Keywords: Hepatitis, HCV, viral polymerase, RNA-dependent-RNA-polymerase, RdRp, resistance, nucleotide analog inhibitor, viral protein, transferase
Deposited on 2014-01-07, released 2014-09-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus JFH-1 [TaxId:356411]
    Gene: POLG_HCVJF
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99IB8 (2-End)
      • expression tag (1)
      • engineered mutation (16)
      • engineered mutation (87-88)
      • engineered mutation (224)
      • engineered mutation (322)
    Domains in SCOPe 2.07: d4obca1, d4obca2
  • Heterogens: MES, GOL, PG6, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4obcA (A:)
mssmsyswtgalitpcgpeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtq
vldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnh
iksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydi
tqklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrhfdstvterdirtees
iyqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvk
alaackaagivaptmlvcgddlivisesqgteedernlrafteamtrysappgdpprpey
dlelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapt
iwvrmvlmthffsilmvqdtldqnlnfemygsvysvnpldlpaiierlhgldafsmhtys
hheltrvasalrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltp
lpearlldlsswftvgagggdifhsvsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4obcA (A:)
ssmsyswtgalitpcgpeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtqv
ldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnhi
ksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydit
qklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrhfdstvterdirteesi
yqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvka
laackaagivaptmlvcgddlivisesqgteedernlrafteamtrysappgdpprpeyd
lelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapti
wvrmvlmthffsilmvqdtldqnlnfemygsvysvnpldlpaiierlhgldafsmhtysh
heltrvasalrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltpl
pearlldlsswftv