PDB entry 4nua

View 4nua on RCSB PDB site
Description: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Class: Transferase
Keywords: Cholesterol Synthesis, Alpha-Helical Prenyltransferase Fold, Transferase, Isoprene Synthesis, Lipid Synthesis, Steroid Biosynthesis, Isoprenoid Pathway, Dimethylallyl Pyrophosphate, Isopentenyl Pyrophosphate
Deposited on 2013-12-03, released 2014-11-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 1.43 Å
R-factor: 0.162
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14324
      • conflict (30)
      • conflict (74)
      • engineered mutation (260)
    Domains in SCOPe 2.07: d4nuaa_
  • Heterogens: RIS, MG, EDO, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nuaA (A:)
mgsshhhhhhssgrenlyfqghmngdqnsdayaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleyntiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgefaqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nuaA (A:)
ayaqekqdfvqhfsqivrvltehpeigdaiarlkevleyntiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekr
yksivkyktafysfylpiaaamymagidgekehanakkillemgefaqiqddyldlfgdp
svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
vflqyeedsyshimalieqyaaplppavflglarkiyk