PDB entry 4lc8

View 4lc8 on RCSB PDB site
Description: Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP
Class: Lyase/Lyase Inhibitor
Keywords: OMPDC fold, orotidine 5'-monophosphate decarboxylase, Lyase-Lyase Inhibitor complex
Deposited on 2013-06-21, released 2013-07-03
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 1.32 Å
R-factor: 0.161
AEROSPACI score: 0.75 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: Methanothermobacter thermautotrophicus [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232 (Start-227)
      • engineered mutation (100)
      • engineered mutation (127)
    Domains in SCOPe 2.03: d4lc8a_
  • Chain 'B':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: Methanothermobacter thermautotrophicus [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • engineered mutation (100)
      • engineered mutation (127)
    Domains in SCOPe 2.03: d4lc8b_
  • Heterogens: BMP, CL, MG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lc8A (A:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemsnpgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgrsiyladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >4lc8A (A:)
dvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcr
iiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltem
snpgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflispgvgaqg
gdpgetlrfadaiivgrsiyladnpaaaaagiiesikdllnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lc8B (B:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemsnpgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgrsiyladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >4lc8B (B:)
mdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcrii
adfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltemsn
pgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflispgvgaqggd
pgetlrfadaiivgrsiyladnpaaaaagiiesikdll