PDB entry 4km2
View 4km2 on RCSB PDB site
Description: Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
Class: oxidoreductase
Keywords: reductase, OXIDOREDUCTASE
Deposited on
2013-05-07, released
2013-12-25
The last revision prior to the SCOPe 2.07 freeze date was dated
2014-01-29, with a file datestamp of
2014-01-24.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.144
AEROSPACI score: 0.63
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: dfrA, folA, MT2833, MTV002.28c, Rv2763c
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4km2a_ - Chain 'B':
Compound: dihydrofolate reductase
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: dfrA, folA, MT2833, MTV002.28c, Rv2763c
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4km2b_ - Heterogens: ATR, TOP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4km2A (A:)
mgsshhhhhhssglvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghti
vmgrrtwdslpakvrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvy
alalpyatrcevtevdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs
Sequence, based on observed residues (ATOM records): (download)
>4km2A (A:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4km2B (B:)
mgsshhhhhhssglvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghti
vmgrrtwdslpakvrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvy
alalpyatrcevtevdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs
Sequence, based on observed residues (ATOM records): (download)
>4km2B (B:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs