PDB entry 4klx

View 4klx on RCSB PDB site
Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation.
Class: oxidoreductase
Keywords: reductase, OXIDOREDUCTASE
Deposited on 2013-05-07, released 2013-12-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-01-29, with a file datestamp of 2014-01-24.
Experiment type: XRAY
Resolution: 1.23 Å
R-factor: 0.183
AEROSPACI score: 0.69 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dfrA, folA, H37Rv, MT2833, MTV002.28c, Rv2763c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A546 (20-178)
      • expression tag (18-19)
    Domains in SCOPe 2.07: d4klxa1, d4klxa2
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dfrA, folA, H37Rv, MT2833, MTV002.28c, Rv2763c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A546 (20-178)
      • expression tag (19)
    Domains in SCOPe 2.07: d4klxb1, d4klxb2
  • Heterogens: ATR, ETE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4klxA (A:)
mgsshhhhhhssglvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghti
vmgrrtwdslpakvrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvy
alalpyatrcevtevdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4klxA (A:)
shmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplp
grrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdig
lpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4klxB (B:)
mgsshhhhhhssglvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghti
vmgrrtwdslpakvrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvy
alalpyatrcevtevdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4klxB (B:)
hmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpg
rrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdigl
preagdalapvldetwrgetgewrfsrsglryrlysyhrs