PDB entry 4jao

View 4jao on RCSB PDB site
Description: Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Class: transferase
Keywords: lipid biosynthesis, Structural Genomics, Enzyme Function Initiative, ketosynthase enzyme, Alkylpyrone synthesis, TRANSFERASE
Deposited on 2013-02-18, released 2013-04-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-11-27, with a file datestamp of 2013-11-22.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.214
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-pyrone synthesis polyketide synthase-like Pks11
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: pks11, Rv1665, MT1705
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jaoa1, d4jaoa2
  • Chain 'B':
    Compound: Alpha-pyrone synthesis polyketide synthase-like Pks11
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: pks11, Rv1665, MT1705
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jaob1, d4jaob2
  • Chain 'C':
    Compound: Alpha-pyrone synthesis polyketide synthase-like Pks11
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: pks11, Rv1665, MT1705
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jaoc1, d4jaoc2
  • Chain 'D':
    Compound: Alpha-pyrone synthesis polyketide synthase-like Pks11
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: pks11, Rv1665, MT1705
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jaod1, d4jaod2
  • Heterogens: PLM, JAO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jaoA (A:)
msviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyp
sltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariag
rlglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvs
slvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlr
lspdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealel
twrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

    Sequence, based on observed residues (ATOM records): (download) 
    >4jaoA (A:)
sviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyps
ltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariagr
lglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvss
lvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlrl
spdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealelt
wrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jaoB (B:)
msviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyp
sltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariag
rlglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvs
slvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlr
lspdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealel
twrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

    Sequence, based on observed residues (ATOM records): (download) 
    >4jaoB (B:)
sviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyps
ltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariagr
lglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvss
lvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlrl
spdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealelt
wrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4jaoC (C:)
msviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyp
sltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariag
rlglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvs
slvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlr
lspdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealel
twrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

    Sequence, based on observed residues (ATOM records): (download) 
    >4jaoC (C:)
sviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyps
ltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariagr
lglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvss
lvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlrl
spdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealelt
wrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4jaoD (D:)
msviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyp
sltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariag
rlglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvs
slvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlr
lspdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealel
twrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr

    Sequence, based on observed residues (ATOM records): (download) 
    >4jaoD (D:)
sviagvfgalpphrysqseitdsfvefpglkeheeiirrlhaaakvngrhlvlplqqyps
ltdfgdaneifiekavdlgveallgalddanlrpsdidmiatatvtgvavpsldariagr
lglrpdvrrmplfglgcvagaagvarlrdylrgapddvavlvsvelcsltypavkptvss
lvgtalfgdgaaavvavgdrraeqvraggpdildsrsslypdslhimgwdvgshglrlrl
spdltnlierylandvttfldahrltkddigawvshpggpkvidavatslalppealelt
wrslgeignlssasilhilrdtiekrppsgsaglmlamgpgfctelvllrwr