PDB entry 4hok

View 4hok on RCSB PDB site
Description: crystal structure of apo ck1e
Class: transferase
Keywords: ck1e, kinase, inhibitor, pf 4800567, transferase
Deposited on 2012-10-22, released 2012-11-14
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-01-02, with a file datestamp of 2012-12-28.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: 0.241
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoka_
  • Chain 'C':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokc_
  • Chain 'E':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoke_
  • Chain 'G':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokg_
  • Chain 'I':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoki_
  • Chain 'K':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokk_
  • Chain 'M':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokm_
  • Chain 'O':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoko_
  • Chain 'Q':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokq_
  • Chain 'S':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoks_
  • Chain 'U':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hoku_
  • Chain 'W':
    Compound: Casein kinase I isoform epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1E
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4hokw_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4hokA (A:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokA (A:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4hokC (C:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokC (C:)
    elrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvgi
    psikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfi
    hrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinth
    lgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgyp
    sefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4hokE (E:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokE (E:)
    melrvgnkyrlgrkigsgdiylganiasgeevaiklecvktkhpqlhieskfykmmqggv
    gipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihskn
    fihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasin
    thlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckg
    ypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4hokG (G:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokG (G:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >4hokI (I:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokI (I:)
    melrvgnkyrlgrkigsgdiylganiasgeevaiklecvktkhpqlhieskfykmmqggv
    gipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihskn
    fihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasin
    thlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckg
    ypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >4hokK (K:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokK (K:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >4hokM (M:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokM (M:)
    rvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykmmqggv
    gipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihskn
    fihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasin
    thlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckg
    ypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'O':
    Sequence, based on SEQRES records: (download)
    >4hokO (O:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokO (O:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'Q':
    Sequence, based on SEQRES records: (download)
    >4hokQ (Q:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokQ (Q:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'S':
    Sequence, based on SEQRES records: (download)
    >4hokS (S:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokS (S:)
    rvgnkyrlgrkigdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvgipsi
    kwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrd
    vkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlgi
    eqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsef
    stylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

  • Chain 'U':
    Sequence, based on SEQRES records: (download)
    >4hokU (U:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokU (U:)
    melrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvg
    ipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknf
    ihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasint
    hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
    psefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml
    

  • Chain 'W':
    Sequence, based on SEQRES records: (download)
    >4hokW (W:)
    gsmelrvgnkyrlgrkigsgsfgdiylganiasgeevaiklecvktkhpqlhieskfykm
    mqggvgipsikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisriey
    ihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtar
    yasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpie
    vlckgypsefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hokW (W:)
    elrvgnkyrlgrkigsdiylganiasgeevaiklecvktkhpqlhieskfykmmqggvgi
    psikwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfi
    hrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinth
    lgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgyp
    sefstylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk