PDB entry 4e76

View 4e76 on RCSB PDB site
Description: Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
Class: viral protein, transferase
Keywords: RDRP, loopless DELTA8, Flaviviridae, hepatitis C virus, VIRAL PROTEIN, TRANSFERASE
Deposited on 2012-03-16, released 2012-04-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:356411]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99IB8 (2-444)
      • expression tag (1)
      • engineered mutation (87-88)
    • Uniprot Q99IB8 (447-End)
      • linker (445-446)
    Domains in SCOPe 2.07: d4e76a1, d4e76a2
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e76A (A:)
mssmsyswtgalitpcspeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtq
vldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnh
iksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydi
tqklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirtees
iyqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvk
alaackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpey
dlelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapt
iwvrmvlmthffsilmvqdtldqnlggvnpldlpaiierlhgldafsmhtyshheltrva
salrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearlld
lsswftvgagggdifhsvsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4e76A (A:)
ssmsyswtgalitpcspeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtqv
ldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnhi
ksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydit
qklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirteesi
yqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvka
laackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeyd
lelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapti
wvrmvlmthffsilmvqdtldqnlggvnpldlpaiierlhgldafsmhtyshheltrvas
alrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearlldl
sswf