PDB entry 4drx

View 4drx on RCSB PDB site
Description: GTP-Tubulin in complex with a DARPIN
Class: cell cycle
Keywords: ALPHA-TUBULIN, BETA-TUBULIN, GTPASE, MICROTUBULE, DARPin, SUBTILISIN, TUBULIN, TUBULIN DIGESTED WITH SUBTILISIN, CELL CYCLE
Deposited on 2012-02-17, released 2012-07-11
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-08-08, with a file datestamp of 2012-08-03.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: 0.161
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWZ0 (Start-436)
      • see remark 999 (231)
      • see remark 999 (339)
    Domains in SCOPe 2.04: d4drxa1, d4drxa2
  • Chain 'B':
    Compound: Tubulin beta chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWY9 (0-430)
      • see remark 999 (315)
    Domains in SCOPe 2.04: d4drxb1, d4drxb2
  • Chain 'C':
    Compound: Tubulin alpha chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWZ0 (Start-436)
      • see remark 999 (231)
      • see remark 999 (339)
    Domains in SCOPe 2.04: d4drxc1, d4drxc2
  • Chain 'D':
    Compound: Tubulin beta chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWY9 (0-430)
      • see remark 999 (315)
    Domains in SCOPe 2.04: d4drxd1, d4drxd2
  • Chain 'E':
    Compound: Designed ankyrin repeat protein (DARPIN) D1
    Species: artificial gene [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4DRX
    Domains in SCOPe 2.04: d4drxe_
  • Chain 'F':
    Compound: Designed ankyrin repeat protein (DARPIN) D1
    Species: artificial gene [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4DRX
    Domains in SCOPe 2.04: d4drxf_
  • Heterogens: GTP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4drxA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgv

    Sequence, based on observed residues (ATOM records): (download) 
    >4drxA (A:)
recisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagkh
vpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldr
irkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstav
vepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitas
lrfdgalnvdltefqtnlvpyprihfplatyapvisaeqlsvaeitnacfepanqmvkcd
prhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpgg
dlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedma
alekdyeevgv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4drxB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatad

    Sequence, based on observed residues (ATOM records): (download) 
    >4drxB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyynvprailvd
lepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvvrkesesc
dclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvvepynatl
svhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttclrfpgqln
adlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmmaacdprh
gryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkmsatf
ignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqqyqd
atad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4drxC (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgv

    Sequence, based on observed residues (ATOM records): (download) 
    >4drxC (C:)
recisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvdl
eptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqct
glqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsilt
thttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgalnv
dltefqtnlvpyprihfplatyapvisaekeqlsvaeitnacfepanqmvkcdprhgkym
accllyrgdvvpkdvnaaiatiktkrsiqfvdwgfkvginyqpptvvpggdlakvqravc
mlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaalekdyeevg
v

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4drxD (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatad

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4drxE (E:)
mrgshhhhhhgsdlgkklleaaragqddevrilmangadvnatdasgltplhlaatyghl
eivevllkhgadvnaidimgstplhlaalighleivevllkhgadvnavdtwgdtplhla
aimghleivevllkhgadvnaqdkfgktafdisidngnedlaeilqkln

    Sequence, based on observed residues (ATOM records): (download) 
    >4drxE (E:)
dlgkklleaaragqddevrilmangadvnatdasgltplhlaatyghleivevllkhgad
vnaidimgstplhlaalighleivevllkhgadvnavdtwgdtplhlaaimghleivevl
lkhgadvnaqdkfgktafdisidngnedlaeilqkl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4drxF (F:)
mrgshhhhhhgsdlgkklleaaragqddevrilmangadvnatdasgltplhlaatyghl
eivevllkhgadvnaidimgstplhlaalighleivevllkhgadvnavdtwgdtplhla
aimghleivevllkhgadvnaqdkfgktafdisidngnedlaeilqkln

    Sequence, based on observed residues (ATOM records): (download) 
    >4drxF (F:)
dlgkklleaaragqddevrilmangadvnatdasgltplhlaatyghleivevllkhgad
vnaidimgstplhlaalighleivevllkhgadvnavdtwgdtplhlaaimghleivevl
lkhgadvnaqdkfgktafdisidngnedlaeilqk