PDB entry 4adp

View 4adp on RCSB PDB site
Description: hcv-j6 ns5b polymerase v405i mutant
Class: transferase
Keywords: hepacivirus, nonstructural proteins, replication, transferase, RNA-directed RNA polymerase, rdrp, de novo initiation, priming
Deposited on 2012-01-02, released 2012-05-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.1729
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9QF35 (2-End)
      • engineered mutation (406)
    Domains in SCOPe 2.07: d4adpa_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4adpA (A:)
masmsyswtgalitpcspeeeklpinplsnsllryhnkvyctttksaslrakkvtfdrmq
vldsyydsvlkdiklaaskvtarlltmeeacqltpphsarskygfgakevrslsgravnh
iksvwkdlledsetpipttimaknevfcvdptkggkkaarlivypdlgvrvcekmalydi
tqklpqavmgasygfqyspaqrvefllkawaekkdpmgfsydtrcfdstvterdirtees
iyracslpeeahtaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvk
alaackaagiiaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpey
dlelitscssnvsvalgpqgrrryyltrdpttpiaraawetvrhspinswlgniiqyapt
iwarmvlmthffsilmaqdtldqnlnfemygavysvspldlpaiierlhgldafslhtyt
pheltrvasalrklgapplrawksraravraslisrggraavcgrylfnwavktklkltp
lpearlldlsswftvgagggdiyhsvsrarprshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4adpA (A:)
smsyswtgalitpcspeeeklpinplsnsllryhnkvyctttksaslrakkvtfdrmqvl
dsyydsvlkdiklaaskvtarlltmeeacqltpphsarskygfgakevrslsgravnhik
svwkdlledsetpipttimaknevfcvdptkggkkaarlivypdlgvrvcekmalyditq
klpqavmgasygfqyspaqrvefllkawaekkdpmgfsydtrcfdstvterdirteesiy
racslpeeahtaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvkal
aackaagiiaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeydl
elitscssnvsvalgpqgrrryyltrdpttpiaraawetvrhspinswlgniiqyaptiw
armvlmthffsilmaqdtldqnlnfemygavysvspldlpaiierlhgldafslhtytph
eltrvasalrklgapplrawksraravraslisrggraavcgrylfnwavktklkltplp
earlldlsswftvgagggdiyhsv