PDB entry 3sci

View 3sci on RCSB PDB site
Description: Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus human strain complexed with human receptor ACE2
Class: hydrolase/viral protein
Keywords: beta sheet, HYDROLASE-VIRAL PROTEIN complex
Deposited on 2011-06-07, released 2012-02-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.229
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3scia_
  • Chain 'B':
    Compound: Angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3scib_
  • Chain 'E':
    Compound: Spike glycoprotein
    Species: SARS coronavirus [TaxId:227859]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P59594
      • conflict (136)
      • conflict (166)
    Domains in SCOPe 2.07: d3scie_
  • Chain 'F':
    Compound: Spike glycoprotein
    Species: SARS coronavirus [TaxId:227859]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P59594
      • conflict (136)
      • conflict (166)
    Domains in SCOPe 2.07: d3scif_
  • Heterogens: ZN, CL

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sciA (A:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhhh
hhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3sciA (A:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sciB (B:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhhh
hhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3sciB (B:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3sciE (E:)
rvvpsgdvvrfpnitnlcpfgevfnatkfpsvyawerkkisncvadysvlynstffstfk
cygvsatklndlcfsnvyadsfvvkgddvrqiapgqtgviadynyklpddfmgcvlawnt
rnidatstgnynykyrflrhgklrpferdisnvpfspdgkpctppafncywplndygfyt
ttgigyqpyrvvvlsfellnapatvcgpklstdliknqcvnfhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3sciE (E:)
cpfgevfnatkfpsvyawerkkisncvadysvlynstffstfkcygvsatklnvyadsfv
vkgddvrqiapgqtgviadynyklpddfmgcvlawntrnidatstgnynykyrflrhgkl
rpferdisnvpfspdgkpctppafncywplndygfytttgigyqpyrvvvlsfe

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3sciF (F:)
rvvpsgdvvrfpnitnlcpfgevfnatkfpsvyawerkkisncvadysvlynstffstfk
cygvsatklndlcfsnvyadsfvvkgddvrqiapgqtgviadynyklpddfmgcvlawnt
rnidatstgnynykyrflrhgklrpferdisnvpfspdgkpctppafncywplndygfyt
ttgigyqpyrvvvlsfellnapatvcgpklstdliknqcvnfhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3sciF (F:)
cpfgevfnatkfpsvyawerkkisncvadysvlynstffstfkcygvsatklnvyadsfv
vkgddvrqiapgqtgviadynyklpddfmgcvlawntrnidatstgnynykyrflrhgkl
rpferdisnvpfspdgkpctppafncywplndygfytttgigyqpyrvvvlsfe