PDB entry 3rtp

View 3rtp on RCSB PDB site
Description: Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Class: transferase/transferase inhibitor
Keywords: JNK inhibitors, pharmacokinetic properties, neurodegeneration, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-05-03, released 2013-05-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-05-08, with a file datestamp of 2013-05-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.24
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK10, JNK3, JNK3A, PRKM10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3rtpa_
  • Heterogens: 34I, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rtpA (A:)
askskvdnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrp
fqnqthakrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviq
meldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsf
mmtpyvvtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieq
lgtpcpefmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllsk
mlvidpakrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykev
mns

    Sequence, based on observed residues (ATOM records): (download) 
    >3rtpA (A:)
nqfysvevgdstftvlkryqnlkpigsgivcaaydavldrnvaikklsrpfqnqthakra
yrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsy
llyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfgltryyrapevilgmgyken
vdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyvenrpk
yagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyinvwy
dpaeveappplderehtieewkeliykevmn