PDB entry 3ps6

View 3ps6 on RCSB PDB site
Description: Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Class: transferase/transferase inhibitor
Keywords: PHOSPHOINOSITIDE KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-11-30, released 2011-02-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-02-23, with a file datestamp of 2011-02-18.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.255
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ps6a1, d3ps6a2, d3ps6a3, d3ps6a4
  • Heterogens: 3PS

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ps6A (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ps6A (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmdfvlrvcgrde
ylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkevslwdcdrkfrvkirgid
ipvlltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiy
cvqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisilldny
pialpraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkw
gqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlh
yllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavile
aylrgcgtamlhdftqqvqviemlqkvtldikslsssqvisqlkqklenlqnsqlpesfr
vpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmli
lqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkd
evlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhid
fghilgnyervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfs
mmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl
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