PDB entry 3phb

View 3phb on RCSB PDB site
Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG
Class: transferase/transferase inhibitor
Keywords: PNP, Immucillin, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-11-03, released 2011-11-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'E':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (32-34)
      • conflict (85)
    Domains in SCOPe 2.07: d3phbe1, d3phbe2
  • Chain 'Q':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
    Domains in SCOPe 2.07: d3phbq1, d3phbq2
  • Chain 'S':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (34)
      • conflict (85)
    Domains in SCOPe 2.07: d3phbs1, d3phbs2
  • Chain 'T':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (32-34)
      • conflict (85)
    Domains in SCOPe 2.07: d3phbt1, d3phbt2
  • Chain 'U':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491
      • conflict (85)
    Domains in SCOPe 2.07: d3phbu_
  • Chain 'Y':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • conflict (85)
    Domains in SCOPe 2.07: d3phby_
  • Heterogens: IM5, PO4, HOH

PDB Chain Sequences:

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3phbE (E:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbE (E:)
ptlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfp
rstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaa
gglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralst
wkqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfg
fslitnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >3phbQ (Q:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbQ (Q:)
tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
slitnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >3phbS (S:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbS (S:)
lmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprs
tvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagg
lnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwk
qmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfs
litnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >3phbT (T:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbT (T:)
ptlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfp
rstvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaa
gglnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralst
wkqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfg
fslitnkvimdyeslekanheevlaagkqaaqkleqfvsilmasipl

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >3phbU (U:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbU (U:)
ngytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvp
ghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnp
kfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmg
eqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslit
nkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpdk

  • Chain 'Y':
    Sequence, based on SEQRES records: (download) 
    >3phbY (Y:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagk
qaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3phbY (Y:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplp