PDB entry 3nzs

View 3nzs on RCSB PDB site
Description: Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
Class: transferase/transferase inhibitor
Keywords: kinase p110, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-07-16, released 2010-12-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-12-29, with a file datestamp of 2010-12-24.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.211
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3nzsa1, d3nzsa2, d3nzsa3, d3nzsa4
  • Heterogens: NZS

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3nzsA (A:)
sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
lpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipesqs
eqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeewplv
ddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfvean
iqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalsskas
aespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkltsat
npdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdplnp
ltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgl
tmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllkrgl
rnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlqkvt
ldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckvmas
kkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlcllp
ygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqaave
rfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkervpfv
ltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqltske
dieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgihhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3nzsA (A:)
sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
lpeylwkkianncifivihrsttsqtikvspddtpgailqsfftdfvlrvcgrdeylvge
tpiknfqwvrhclkngeeihvvldtppdpaldevrkslwdcdrkfrvkirgidipvlprn
tdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycq
llyyvnlllidhrfllrrgeyvlhmwqisfnadkltsatnpdkensmsisilldalpkem
pnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivakt
yqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqav
kfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgta
mlhdftqqvqviemlqkvtldikslydvssqvisqlkqklenlqnsqlpesfrvpydpgl
kagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrim
esiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwl
kekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghirvp
fvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlts
kedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl