PDB entry 3mk8

View 3mk8 on RCSB PDB site
Description: The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer
Class: apoptosis/apoptosis regulator
Keywords: MCL-1, MCL-1 SAHB D, staple, SAHB, BCL-2 family, apoptosis, anti-apoptotic, APOPTOSIS-APOPTOSIS REGULATOR complex
Deposited on 2010-04-14, released 2010-06-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-08-04, with a file datestamp of 2010-07-30.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: 0.233
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L3, mcl-1, MCL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3mk8a_
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820
      • engineered (13)
      • engineered (17)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mk8A (A:)
gsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3mk8A (A:)
delyrqsleiisrylreqatgasgatsrkaletlrrvgdgvqrnhetafqgmlrkldikn
eddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvlv
rtkrdwlvkqrgwdgfveffh

  • Chain 'B':
    No sequence available.