PDB entry 3lc3
View 3lc3 on RCSB PDB site
Description: Benzothiophene Inhibitors of Factor IXa
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Protein-Inhibitor complex, Peptidase S1, Blood coagulation, Calcium, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, EGF-like domain, Gamma-carboxyglutamic acid, Glycoprotein, Hemophilia, Hydrolase, Hydroxylation, Pharmaceutical, Phosphoprotein, Polymorphism, Protease, Secreted, Serine protease, Sulfation, Zymogen, Hydrolase-Hydrolase Inhibitor complex
Deposited on
2010-01-09, released
2010-02-23
The last revision prior to the SCOPe 2.07 freeze date was dated
2010-03-02, with a file datestamp of
2010-02-26.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.199
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3lc3a_ - Chain 'B':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
- Uniprot P00740 (1-56)
- initiating methionine (0)
Domains in SCOPe 2.07: d3lc3b_ - Chain 'C':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3lc3c_ - Chain 'D':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
- Uniprot P00740 (1-56)
- initiating methionine (0)
Domains in SCOPe 2.07: d3lc3d_ - Heterogens: IYX, CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3lc3A (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3lc3B (B:)
mtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtsk
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>3lc3C (C:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>3lc3D (D:)
mtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtsk