PDB entry 3kec

View 3kec on RCSB PDB site
Description: Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound
Class: hydrolase/hydrolase inhibitor
Keywords: S1' inhibitor; selective MMP-13 inhibitor; S1' specificity pocket; no contact to Zn, Collagen degradation, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Protease, Secreted, Zymogen, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2009-10-25, released 2010-11-10
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-02-16, with a file datestamp of 2011-02-11.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.17
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: collagenase 3
  Species: Homo sapiens [TaxId:9606]
  Gene: MMP13
  Database cross-references and differences (RAF-indexed):
  • Uniprot P45452 (1-163)
    • expression tag (0)
    • expression tag (164-166)
  Domains in SCOPe 2.03: d3keca_
• Chain 'B':
  Compound: collagenase 3
  Species: Homo sapiens [TaxId:9606]
  Gene: MMP13
  Database cross-references and differences (RAF-indexed):
  • Uniprot P45452 (1-163)
    • expression tag (0)
    • expression tag (164-166)
  Domains in SCOPe 2.03: d3kecb_
• Heterogens: ZN, CA, SO4, 3KE, HAE, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3kecA (A:)
  ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
  misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
  fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3kecB (B:)
  ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
  misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
  fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd