PDB entry 3iqk

View 3iqk on RCSB PDB site
Description: Human Carbonic Anhydrase II H64A complexed with Thioxolone hydrolysis products
Class: lyase
Keywords: CARBONIC ANHYDRASE II, HUMAN CARBONIC ANHYDRASE II, HCA II, HCA2, CA II, CA2, Carbonate dehydratase II, Carbonic anhydrase C, THIOXOLONE, 4-MERCAPTOBENZENE-1,3-DIOL, 4-(2,4-DIHYDROXYPHENYL)DISULFANYLBENZENE-1,3-DIOL, Disease mutation, Lyase, Metal-binding
Deposited on 2009-08-20, released 2010-08-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: 0.125
AEROSPACI score: 0.86 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CA2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00918 (Start-259)
      • engineered (63)
    Domains in SCOPe 2.07: d3iqka_
  • Heterogens: ZN, TH7, D2S, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3iqkA (A:)
mshhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslril
nngaafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhl
vhwntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdp
rgllpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelm
vdnwrpaqplknrqikasfk

    Sequence, based on observed residues (ATOM records): (download) 
    >3iqkA (A:)
hwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnng
aafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvhw
ntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgl
lpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvdn
wrpaqplknrqikasfk