PDB entry 3hdz
View 3hdz on RCSB PDB site
Description: Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors
Class: Hydrolase
Keywords: PDE5, PDE-5,inhibition, Alternative splicing, cAMP, Hydrolase, Phosphoprotein, Polymorphism Allosteric enzyme, cGMP, cGMP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc
Deposited on
2009-05-07, released
2009-07-07
The last revision prior to the SCOPe 2.04 freeze date was dated
2009-07-07, with a file datestamp of
2009-07-02.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.181
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cGMP-specific 3',5'-cyclic phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Species: Homo sapiens [TaxId:9606]
Gene: PDE5A, PDE5, PDE4B, DPDE4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d3hdza_ - Heterogens: PD6, ZN, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hdzA (A:)
etrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevl
crwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdl
dhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphekelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalae
Sequence, based on observed residues (ATOM records): (download)
>3hdzA (A:)
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeykttlki
ikqailatdlalyikrrgeffelirknqfnledphekelflamlmtacdlsaitkpwpiq
qriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthv
sedcfplldgcrknrqkwqalae