PDB entry 3gol

View 3gol on RCSB PDB site
Description: HCV NS5b polymerase in complex with 1,5 benzodiazepine inhibitor (R)-11d
Class: transferase
Keywords: 1,5-Benzodiazepine, HCV Polymerase, NS5B, medicinal chemistry, 1b-J4, TRANSFERASE
Deposited on 2009-03-19, released 2009-06-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.191
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3gola_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3golb_
  • Heterogens: XND, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3golA (A:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3golA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
lsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3golB (B:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3golB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
avmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccd
lapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacr
aaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinr
vasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasq
ldlsgwfvagysggdiyhs