PDB entry 3g86

View 3g86 on RCSB PDB site
Description: Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor
Class: transferase
Keywords: HCV, HEPATITIS, NS5B, TRANSFERASE RNA-DEPENDENT RNA POLYMERASE, Acetylation, Apoptosis, ATP-binding, Capsid protein, Cell membrane, Cytoplasm, Endoplasmic reticulum, Envelope protein, Fusion protein, Glycoprotein, Helicase, Host-virus interaction, Hydrolase, Interferon antiviral system evasion, Lipid droplet, Lipoprotein, Membrane, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Nucleus, Oncogene, Palmitate, Phosphoprotein, Protease, Ribonucleoprotein, RNA replication, RNA-binding, RNA-directed RNA polymerase, Secreted, Serine protease, SH3-binding, Thiol protease, Transcription, Transcription regulation, Transferase, Transmembrane, Ubl conjugation, Viral nucleoprotein, Virion, Zinc
Deposited on 2009-02-11, released 2009-09-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-09-08, with a file datestamp of 2009-09-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.192
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11105]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.07: d3g86a1, d3g86a2
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11105]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d3g86b1, d3g86b2
  • Heterogens: T18, NI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g86A (A:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3g86A (A:)
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g86B (B:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3g86B (B:)
hhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasr
ldlsgwfvagysggdiyh