PDB entry 3fh7

View 3fh7 on RCSB PDB site
Description: Leukotriene A4 Hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate.
Class: hydrolase/hydrolase inhibitor
Keywords: LTA4H, Leukotriene A4, Leukotriene B4 Biosynthesis, Peptidase, Hydrolase-hydrolase inhibitor complex, Structure Based Drug Design, Leukotriene biosynthesis, Metal-binding, Metalloprotease, Multifunctional enzyme, Protease
Deposited on 2008-12-08, released 2010-01-05
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.171
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leukotriene A-4 hydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: LTA4H, LTA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3fh7a1, d3fh7a2, d3fh7a3
  • Heterogens: ZN, YB, ACT, IMD, 25P, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fh7A (A:)
mpeivdtcslaspasvcrtkhlhlrcsvdftrrtltgtaaltvqsqednlrslvldtkdl
tiekvvingqevkyalgerqsykgspmeislpialsknqeivieisfetspkssalqwlt
peqtsgkehpylfsqcqaihcrailpcqdtpsvkltytaevsvpkelvalmsairdgetp
dpedpsrkiykfiqkvpipcylialvvgalesrqigprtlvwsekeqveksayefsetes
mlkiaedlggpyvwgqydllvlppsfpyggmenpcltfvtptllagdkslsnviaheish
swtgnlvtnktwdhfwlneghtvylerhicgrlfgekfrhfnalggwgelqnsvktfget
hpftklvvdltdidpdvayssvpyekgfallfyleqllggpeiflgflkayvekfsyksi
ttddwkdflysyfkdkvdvlnqvdwnawlyspglppikpnydmtltnacialsqrwitak
eddlnsfnatdlkdlsshqlneflaqtlqraplplghikrmqevynfnainnseirfrwl
rlciqskwedaiplalkmateqgrmkftrplfkdlaafdkshdqavrtyqehkasmhpvt
amlvgkdlkvd

    Sequence, based on observed residues (ATOM records): (download) 
    >3fh7A (A:)
vdtcslaspasvcrtkhlhlrcsvdftrrtltgtaaltvqsqednlrslvldtkdltiek
vvingqevkyalgerqsykgspmeislpialsknqeivieisfetspkssalqwltpeqt
sgkehpylfsqcqaihcrailpcqdtpsvkltytaevsvpkelvalmsairdgetpdped
psrkiykfiqkvpipcylialvvgalesrqigprtlvwsekeqveksayefsetesmlki
aedlggpyvwgqydllvlppsfpyggmenpcltfvtptllagdkslsnviaheishswtg
nlvtnktwdhfwlneghtvylerhicgrlfgekfrhfnalggwgelqnsvktfgethpft
klvvdltdidpdvayssvpyekgfallfyleqllggpeiflgflkayvekfsyksittdd
wkdflysyfkdkvdvlnqvdwnawlyspglppikpnydmtltnacialsqrwitakeddl
nsfnatdlkdlsshqlneflaqtlqraplplghikrmqevynfnainnseirfrwlrlci
qskwedaiplalkmateqgrmkftrplfkdlaafdkshdqavrtyqehkasmhpvtamlv
gkdlkvd