PDB entry 3exf

View 3exf on RCSB PDB site
Description: Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex
Class: oxidoreductase
Keywords: heterotetramer; thiamine diphosphate-dependent enzyme; Disease mutation; Glycolysis; Leigh syndrome; Mitochondrion; Oxidoreductase; Phosphoprotein; Alternative splicing; Polymorphism; Pyruvate; Thiamine pyrophosphate; Transit peptide, OXIDOREDUCTASE
Deposited on 2008-10-16, released 2008-11-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (20)
      • engineered (223)
      • engineered (291)
    Domains in SCOPe 2.07: d3exfa1, d3exfa2
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3exfb1, d3exfb2
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (19-20)
      • engineered (223)
      • engineered (291)
    Domains in SCOPe 2.07: d3exfc1, d3exfc2
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3exfd1, d3exfd2
  • Chain 'E':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (19-20)
      • engineered (223)
      • engineered (291)
    Domains in SCOPe 2.07: d3exfe1, d3exfe2
  • Chain 'F':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3exff1, d3exff2
  • Chain 'G':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (20)
      • engineered (223)
      • engineered (291)
    Domains in SCOPe 2.07: d3exfg1, d3exfg2
  • Chain 'H':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3exfh1, d3exfh2
  • Heterogens: MG, TPP, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3exfA (A:)
mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtaveraaastdyykrgdf
ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiq
evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
yssdppfevrganqwikfksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >3exfA (A:)
mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtaveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3exfB (B:)
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
pmpyakilednsipqvkdiifaikktlni

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3exfC (C:)
mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtaveraaastdyykrgdf
ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiq
evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
yssdppfevrganqwikfksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >3exfC (C:)
hmfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkii
rgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcak
gkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifea
ynmaalwklpcificennrygmgtaveraaastdyykrgdfipglrvdgmdilcvreatr
faaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiqevrsksdpimllkdrmvns
nlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfk
svs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3exfD (D:)
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
pmpyakilednsipqvkdiifaikktlni

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3exfE (E:)
mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtaveraaastdyykrgdf
ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiq
evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
yssdppfevrganqwikfksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >3exfE (E:)
hmfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkii
rgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcak
gkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifea
ynmaalwklpcificennrygmgtaveraaastdyykrgdfipglrvdgmdilcvreatr
faaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiqevrsksdpimllkdrmvns
nlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfk
svs

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3exfF (F:)
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
pmpyakilednsipqvkdiifaikktlni

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3exfG (G:)
mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtaveraaastdyykrgdf
ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiq
evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
yssdppfevrganqwikfksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >3exfG (G:)
mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtaveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghsmsdpgvayrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3exfH (H:)
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
pmpyakilednsipqvkdiifaikktlni