PDB entry 3e7a

View 3e7a on RCSB PDB site
Description: Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin Nodularin-R
Class: hydrolase/hydrolase inhibitor
Keywords: Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Hydrolase, Iron, Manganese, Metal-binding, Phosphoprotein, Protein phosphatase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2008-08-18, released 2008-11-04
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-04-10, with a file datestamp of 2013-04-05.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: 0.144
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1CA, PPP1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3e7aa_
  • Chain 'B':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1CA, PPP1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3e7ab_
  • Chain 'C':
    Compound: nodularin R
    Species: Nodularia spumigena, synthetic [TaxId:70799]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00279 (0-4)
  • Chain 'D':
    Compound: nodularin R
    Species: Nodularia spumigena, synthetic [TaxId:70799]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00279 (0-4)
  • Heterogens: MN, IOD, CL, GOL, AZI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e7aA (A:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpad

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7aA (A:)
lnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdih
gqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnhe
casinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeqi
rrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlicr
ahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e7aB (B:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpad

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7aB (B:)
lnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdih
gqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnhe
casinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeqi
rrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlicr
ahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.