PDB entry 3c16

View 3c16 on RCSB PDB site
Description: Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca
Class: Lyase/Lyase INHIBITOR
Keywords: ADENYLYL CYCLASE, GSALPHA, cAMP biosynthesis, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Phosphoprotein, Transmembrane, GTP-binding, Lipoprotein, Nucleotide-binding, Palmitate, Transducer, Lyase-Lyase INHIBITOR COMPLEX
Deposited on 2008-01-22, released 2009-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-08-17, with a file datestamp of 2011-08-12.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: 0.252
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Adenylate cyclase type 5
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: ADCY5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30803
      • engineered (120)
    Domains in SCOPe 2.07: d3c16a_
  • Chain 'B':
    Compound: Adenylate cyclase type 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Adcy2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3c16b_
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Bos taurus [TaxId:9913]
    Gene: GNAS, GNAS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3c16c1, d3c16c2
  • Heterogens: CL, MG, CA, GSP, FOK, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c16A (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak

    Sequence, based on observed residues (ATOM records): (download) 
    >3c16A (A:)
dmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclri
kilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcg
vlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylk
ehsietflil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3c16B (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3c16B (B:)
hqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgvekik
tigstymaatglsqymhigtmvefayalvgkldainkhsfndfklrvginhgpviagvig
aqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgkgdlk
tyfvnt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3c16C (C:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyellgghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3c16C (C:)
athrllllgagesgkstivkqmrilhvngekatkvqdiknnlkeaietivaamsnlvppv
elanpenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqy
fldkidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqc
fndvtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdll
aekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrh
ycyphftcavdtenirrvfndcrdiiqrmhl