PDB entry 2wb5

View 2wb5 on RCSB PDB site
Description: glcnacstatins are nanomolar inhibitors of human o-glcnacase inducing cellular hyper-o-glcnacylation
Class: hydrolase
Keywords: hydrolase, glycosidase
Deposited on 2009-02-20, released 2009-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-12-21, with a file datestamp of 2011-12-16.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: 0.18683
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: O-GlcNAcase nagJ
    Species: Clostridium perfringens [TaxId:1502]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q0TR53 (Start-593)
      • conflict (357)
    Domains in SCOPe 2.08: d2wb5a1, d2wb5a2, d2wb5a3
  • Chain 'B':
    Compound: O-GlcNAcase nagJ
    Species: Clostridium perfringens [TaxId:1502]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q0TR53 (Start-593)
      • conflict (357)
    Domains in SCOPe 2.08: d2wb5b1, d2wb5b2, d2wb5b3
  • Heterogens: CL, NA, VGB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wb5A (A:)
    vgpktgeenqvlvpnlnptpenlevvgdgfkitssinlvgeeeadenavnalrefltann
    ieinsendpnsttliigevdddipeldealngttaenlkeegyalvsndgkiaiegkdgd
    gtfygvqtfkqlvkesnipevnitdyptvsargivegfygtpwthqdrldqikfygenkl
    ntyiyapkddpyhrekwrepypesemqrmqelinasaenkvdfvfgispgidirfdgdag
    eedfnhlitkaeslydmgvrsfaiywddiqdksaakhaqvlnrfneefvkakgdvkplit
    vpteydtgamvsngqpraytrifaetvdpsievmwtgpgvvtneiplsdaqlisgiydrn
    mavwwnypvtdyfkgklalgpmhgldkglnqyvdfftvnpmehaelskisihtaadyswn
    mdnydydkawnraidmlygdlaedmkvfanhstrmdnktwaksgredapelrakmdelwn
    klsskedasalieelygefarmeeacnnlkanlpevaleecsrqldelitlaqgdkasld
    mivaqlnedteayesakeiaqnklntalssfavisekvaqsfiqealsfdltli
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wb5A (A:)
    qvlvpnlnptpenlevvgdgfkitssinlvgeeeadenavnalrefltannieinsendp
    nsttliigevdddipeldealngttaenlkeegyalvsndgkiaiegkdgdgtfygvqtf
    kqlvkesnipevnitdyptvsargivegfygtpwthqdrldqikfygenklntyiyapkd
    dpyhrekwrepypesemqrmqelinasaenkvdfvfgispgidirfdgdageedfnhlit
    kaeslydmgvrsfaiywddiqdksaakhaqvlnrfneefvkakgdvkplitvpteydtga
    mvsngqpraytrifaetvdpsievmwtgpgvvtneiplsdaqlisgiydrnmavwwnypv
    tdyfkgklalgpmhgldkglnqyvdfftvnpmehaelskisihtaadyswnmdnydydka
    wnraidmlygdlaedmkvfanhstrmdnktwaksgredapelrakmdelwnklsskedas
    alieelygefarmeeacnnlkanlpevaleecsrqldelitlaqgdkasldmivaqlned
    teayesakeiaqnklntalssfavisekvaqsfiqealsfdltli
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2wb5B (B:)
    vgpktgeenqvlvpnlnptpenlevvgdgfkitssinlvgeeeadenavnalrefltann
    ieinsendpnsttliigevdddipeldealngttaenlkeegyalvsndgkiaiegkdgd
    gtfygvqtfkqlvkesnipevnitdyptvsargivegfygtpwthqdrldqikfygenkl
    ntyiyapkddpyhrekwrepypesemqrmqelinasaenkvdfvfgispgidirfdgdag
    eedfnhlitkaeslydmgvrsfaiywddiqdksaakhaqvlnrfneefvkakgdvkplit
    vpteydtgamvsngqpraytrifaetvdpsievmwtgpgvvtneiplsdaqlisgiydrn
    mavwwnypvtdyfkgklalgpmhgldkglnqyvdfftvnpmehaelskisihtaadyswn
    mdnydydkawnraidmlygdlaedmkvfanhstrmdnktwaksgredapelrakmdelwn
    klsskedasalieelygefarmeeacnnlkanlpevaleecsrqldelitlaqgdkasld
    mivaqlnedteayesakeiaqnklntalssfavisekvaqsfiqealsfdltli
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wb5B (B:)
    qvlvpnlnptpenlevvgdgfkitssinlvgeeeadenavnalrefltannieinsendp
    nsttliigevdddipeldealngttaenlkeegyalvsndgkiaiegkdgdgtfygvqtf
    kqlvkesnipevnitdyptvsargivegfygtpwthqdrldqikfygenklntyiyapkd
    dpyhrekwrepypesemqrmqelinasaenkvdfvfgispgidirfdgdageedfnhlit
    kaeslydmgvrsfaiywddiqdksaakhaqvlnrfneefvkakgdvkplitvpteydtga
    mvsngqpraytrifaetvdpsievmwtgpgvvtneiplsdaqlisgiydrnmavwwnypv
    tdyfkgklalgpmhgldkglnqyvdfftvnpmehaelskisihtaadyswnmdnydydka
    wnraidmlygdlaedmkvfanhstrmdnktwaksgredapelrakmdelwnklsskedas
    alieelygefarmeeacnnlkanlpevaleecsrqldelitlaqgdkasldmivaqlned
    teayesakeiaqnklntalssfavisekvaqsfiqealsfdltli