PDB entry 2w79

View 2w79 on RCSB PDB site
Description: establishing wild-type levels of catalytic activity on natural and artificial (ba)8-barrel protein scaffolds
Class: isomerase
Keywords: isomerase, histidine biosynthesis, amino-acid biosynthesis
Deposited on 2008-12-21, released 2009-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.206
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9X0C7 (0-240)
      • engineered mutation (74)
      • engineered mutation (110)
      • engineered mutation (126)
      • engineered mutation (168)
    Domains in SCOPe 2.07: d2w79a_
  • Chain 'B':
    Compound: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9X0C7 (0-240)
      • engineered mutation (74)
      • engineered mutation (110)
      • engineered mutation (126)
      • engineered mutation (168)
    Domains in SCOPe 2.07: d2w79b_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2w79A (A:)
mlvvpaidlfrgkvarmikgrkentifyekdpvelveklieegftlihvvdlsnaiensg
enlpvleklsefaeyiqigggirsldyaeklrklgyrrqivsskvledpsslkslreidv
epvfslvtrggrvafkgwlaeeeidpvsllkrlkeygleeivhteiekvgtlqehdfslt
kkiaieaevkvlaaggissenslktaqkvhtetngllkgvivgraflegiltvevmkrya
r

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w79B (B:)
mlvvpaidlfrgkvarmikgrkentifyekdpvelveklieegftlihvvdlsnaiensg
enlpvleklsefaeyiqigggirsldyaeklrklgyrrqivsskvledpsslkslreidv
epvfslvtrggrvafkgwlaeeeidpvsllkrlkeygleeivhteiekvgtlqehdfslt
kkiaieaevkvlaaggissenslktaqkvhtetngllkgvivgraflegiltvevmkrya
r

    Sequence, based on observed residues (ATOM records): (download) 
    >2w79B (B:)
mlvvpaidlfrgkvarmikgrkentifyekdpvelveklieegftlihvvdlsnaiensg
enlpvleklsefaeyiqigggirsldyaeklrklgyrrqivsskvledpsslkslreidv
epvfslvtrggrvafkgwlaeidpvsllkrlkeygleeivhteiekvgtlqehdfsltkk
iaieaevkvlaaggissenslktaqkvhtetngllkgvivgraflegiltvevmkryar