PDB entry 2itu
View 2itu on RCSB PDB site
Description: Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941
Class: transferase
Keywords: receptor, cell cycle, ATP-binding, transferase, transmembrane, phosphorylation, disease mutation, glycoprotein, anti-oncogene, nucleotide-binding, afn941, egfr, l858r, staurosporine, membrane tyrosine-protein kinase, epidermal growth factor
Deposited on
2006-05-25, released
2007-04-03
The last revision prior to the SCOPe 2.03 freeze date was dated
2013-03-27, with a file datestamp of
2013-03-22.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.201
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (0-End)
- engineered mutation (162)
Domains in SCOPe 2.03: d2itua_ - Heterogens: ITQ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2ituA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>2ituA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaevpikwmales
ilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvym
imvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsmdeedmddvvdade
ylip