PDB entry 2hvl

View 2hvl on RCSB PDB site
Description: Crystal structure of the HePTP catalytic domain C270S mutant
Class: Hydrolase
Keywords: HePTP, Human Tyrosine Phosphatase Catalytic Domain, Lc-PTP, PTPN7, Substrate-trapping mutant, Hydrolase
Deposited on 2006-07-29, released 2007-08-07
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 7
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35236 (13-End)
      • engineered (239)
    Domains in SCOPe 2.03: d2hvla_
  • Heterogens: PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hvlA (A:)
mgsdkihhhhhhmntprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvsp
edldipghaskdryktilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgp
mpntvsdfwemvwqeevslivmltqlregkekcvhywpteeetygpfqiriqdmkecpey
tvrqltiqyqeerrsvkhilfsawpdhqtpesagpllrlvaeveespetaahpgpivvhs
sagigrtgcfiatrigcqqlkargevdilgivcqlrldrggmiqtaeqyqflhhtlalya
gqlpeepsp

    Sequence, based on observed residues (ATOM records): (download) 
    >2hvlA (A:)
ntprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvspedldipghaskdr
yktilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgpmpntvsdfwemvw
qeevslivmltqlcvhywpteeetygpfqiriqdmkecpeytvrqltiqyqeerrsvkhi
lfsawpdhqtpesagpllrlvaeveespetaahpgpivvhssagigrtgcfiatrigcqq
lkargevdilgivcqlrldrggmiqtaeqyqflhhtlalyagqlp