PDB entry 2fpy

View 2fpy on RCSB PDB site
Description: Dual binding mode of a novel series of DHODH inhibitors
Class: oxidoreductase
Keywords: protein inhibitor complex, OXIDOREDUCTASE
Deposited on 2006-01-17, released 2007-01-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.181
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2fpya_
  • Heterogens: ACT, SO4, FMN, ORO, ILF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fpyA (A:)
mghhhhhhhhhhssghiddddkhmledpmatgderfyaehlmptlqglldpesahrlavr
ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
wgppvvgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2fpyA (A:)
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr