PDB entry 2f9b

View 2f9b on RCSB PDB site
Description: Discovery of Novel Heterocyclic Factor VIIa Inhibitors
Class: hydrolase/blood clotting
Keywords: serine protease, short hydrogen bond, active site-directed inhibitor, HYDROLASE/BLOOD CLOTTING COMPLEX
Deposited on 2005-12-05, released 2006-02-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: 0.226
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2f9bh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2f9bl1, d2f9bl2
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2f9bt1, d2f9bt2
  • Heterogens: N1H, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2f9bH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2f9bL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipilekrnaskpqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9bL (L:)
qcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgt
krscrchegyslladgvsctptveypcgkipile

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >2f9bT (T:)
gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
genycfsvqavipsrtvnrkstdspvecmgqekgefre

    Sequence, based on observed residues (ATOM records): (download) 
    >2f9bT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
dvfgkdliytlsvqavipsrtvnrkstds