SCOPe 2.07: Structural Classification of Proteins

PDB entry 2awz

View 2awz on RCSB PDB site
Description: Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)
Class: transferase
Keywords: HCV, NS5B, Polymerase, Fingers, Thumb, Palm, TRANSFERASE
Deposited on 2005-09-02, released 2006-01-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.205
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Genome polyprotein
Species: Hepatitis C virus [TaxId:11103]
Database cross-references and differences (RAF-indexed):
- Uniprot P26663 (0-End)
  - engineered (498)
  - engineered (505)
  - engineered (513)
  - engineered (519)
  - engineered (539)
  - engineered (548)
  - engineered (551)
Domains in SCOPe 2.07: d2awza_
Chain 'B':
Compound: Genome polyprotein
Species: Hepatitis C virus [TaxId:11103]
Database cross-references and differences (RAF-indexed):
- Uniprot P26663 (0-End)
  - engineered (498)
  - engineered (505)
  - engineered (513)
  - engineered (519)
  - engineered (539)
  - engineered (542)
  - engineered (548)
  - engineered (551)
Domains in SCOPe 2.07: d2awzb_
Heterogens: SO4, 5H, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2awzA (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrawrhrarnvrarllsrggraaicgkylfnwavktklkltpia
aagrldlsswftagysggdiyhgvsharprhhhhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2awzA (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrawrhrarnvrarllsrggraaicgkylfnwavktklkltpia
dlsswftagysggdiyh

Chain 'B':
Sequence, based on SEQRES records: (download)

>2awzB (B:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrawrhrarnvrarllsrggraaicgkylfnwavktklkltpia
aagrldlsswftagysggdiyhgvsharprhhhhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2awzB (B:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrawrhrarnvrarllsrggraaicgkylfnwavktklkltpia
aagrldlsswftagysggdiyh