PDB entry 2ajl

View 2ajl on RCSB PDB site
Description: X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
Class: hydrolase
Keywords: Aminopeptidase, hydrolase, protease, serine protease
Deposited on 2005-08-02, released 2005-11-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.226
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2ajli1, d2ajli2
  • Chain 'J':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2ajlj1, d2ajlj2
  • Heterogens: NAG, JNH, HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2ajlI (I:)
srktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
lnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >2ajlI (I:)
ktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefgh
sindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspv
ghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspng
tflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvt
natsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwncl
varqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkg
twevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvs
fskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiiln
etkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdg
rgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvl
gsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqvey
llihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfik
qcfslp

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ajlJ (J:)
srktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
lnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp