PDB entry 1yho

View 1yho on RCSB PDB site
Description: Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Class: oxidoreductase
Keywords: DHFR, Inhibitor/Enzyme complex, OXIDOREDUCTASE
Deposited on 2005-01-10, released 2005-11-22
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: NMR
Resolution: N/A
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00374 (0-185)
  Domains in SCOPe 2.03: d1yhoa1
• Heterogens: NDP, TRR

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1yhoA (A:)
  vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
  peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
  ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
  vyeknd