PDB entry 1xmj

View 1xmj on RCSB PDB site
Description: Crystal structure of human deltaF508 human NBD1 domain with ATP
Class: membrane protein, hydrolase
Keywords: CFTR; NBD1 domain; deltaF508; cystic fibrosis; nucleotide-binding domain 1, MEMBRANE PROTEIN, HYDROLASE
Deposited on 2004-10-02, released 2004-11-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.248
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569
      • engineered (161)
      • engineered (163)
      • engineered (166)
      • engineered (278)
    Domains in SCOPe 2.04: d1xmja_
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xmjA (A:)
sttevvmenvtafweegfgellekakqnnnnrktsngddslsfsnlsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
gvsydeyryrsvikacqleediskfaekdnivlgeggitlsegqqakislaravykdadl
ylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfyg
tfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmjA (A:)
evvmenvtafwetpvlkdinfkiergqllavagstgagktsllmmimgelepsegkikhs
grisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdnivlgeggi
tlsegqqakislaravykdadlylldspfgyldvltekeifescvcklmanktrilvtsk
mehlkkadkililhegssyfygtfselqnlqpdfssklmsfdqfsaerrnsiltetlrrf
slegda