PDB entry 1wuu

View 1wuu on RCSB PDB site
Description: crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Class: transferase
Keywords: galactosemia, GHMP superfamily, kinase, TRANSFERASE
Deposited on 2004-12-08, released 2004-12-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.205
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • expression tag (6-7)
      • modified residue (61)
      • modified residue (66)
      • modified residue (186)
      • modified residue (191)
      • modified residue (198)
      • modified residue (313)
      • modified residue (349)
      • modified residue (371)
    Domains in SCOPe 2.04: d1wuua1, d1wuua2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • modified residue (61)
      • modified residue (66)
      • modified residue (186)
      • modified residue (191)
      • modified residue (198)
      • modified residue (313)
      • modified residue (349)
      • modified residue (371)
    Domains in SCOPe 2.04: d1wuub1, d1wuub2
  • Chain 'C':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • expression tag (7)
      • modified residue (61)
      • modified residue (66)
      • modified residue (186)
      • modified residue (191)
      • modified residue (198)
      • modified residue (313)
      • modified residue (349)
      • modified residue (371)
    Domains in SCOPe 2.04: d1wuuc1, d1wuuc2
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (8-398)
      • expression tag (7)
      • modified residue (61)
      • modified residue (66)
      • modified residue (186)
      • modified residue (191)
      • modified residue (198)
      • modified residue (313)
      • modified residue (349)
      • modified residue (371)
    Domains in SCOPe 2.04: d1wuud1, d1wuud2
  • Heterogens: GLA, MG, ANP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wuuA (A:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >1wuuA (A:)
hhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalel
mtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypa
aplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfag
mpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhasseypvrrr
qceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1wuuB (B:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >1wuuB (B:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhlasseypvrrrq
ceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyra
fgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaap
hamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1wuuC (C:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >1wuuC (C:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhasseypvrrrq
ceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyra
fgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaap
hamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1wuuD (D:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >1wuuD (D:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhssseypvrrrq
ceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyra
fgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaap
hamrhiqehyggtatfylsqaadgakvlcl