PDB entry 1sej

View 1sej on RCSB PDB site
Description: Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP
Class: transferase, oxidoreductase
Keywords: bifunctional enzyme, TRANSFERASE, OXIDOREDUCTASE
Deposited on 2004-02-17, released 2004-05-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1seja1, d1seja2
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sejb1, d1sejb2
  • Chain 'C':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sejc1, d1sejc2
  • Chain 'D':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sejd1, d1sejd2
  • Chain 'E':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1seje1, d1seje2
  • Heterogens: UMP, F89, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1sejA (A:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >1sejA (A:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkt
lqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyld
llsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgd
tngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytg
vgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyq
rscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtpr
pfpqlkfkrkveniedfkwedieligyypyptikmdmav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1sejB (B:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >1sejB (B:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkt
lqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyld
llsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgd
tngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytg
vgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyq
rscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtpr
pfpqlkfkrkveniedfkwedieligyypyptikmdmav

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1sejC (C:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >1sejC (C:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkt
lqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyld
llsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgd
tngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytg
vgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyq
rscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtpr
pfpqlkfkrkveniedfkwedieligyypyptikmdmav

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1sejD (D:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >1sejD (D:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkt
lqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyld
llsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgd
tngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytg
vgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyq
rscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtpr
pfpqlkfkrkveniedfkwedieligyypyptikmdmav

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1sejE (E:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >1sejE (E:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkt
lqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyld
llsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgd
tngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytg
vgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyq
rscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtpr
pfpqlkfkrkveniedfkwedieligyypyptikmdmav