PDB entry 1lcy

View 1lcy on RCSB PDB site
Description: Crystal Structure of the Mitochondrial Serine Protease HtrA2
Class: hydrolase
Keywords: apoptosis, serine protease, PDZ domain, caspase activation, IAP-binding
Deposited on 2002-04-07, released 2002-05-22
The last revision prior to the SCOP 1.75 freeze date was dated 2005-07-19, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.235
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HtrA2 serine protease
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43464 (Start-324)
      • engineered (172)
    Domains in SCOP 1.75: d1lcya1, d1lcya2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lcyA (A:)
avpspppasprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadgli
vtnahvvadrrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvrq
gefvvamgspfalqntitsgivssaqrpardlglpqtnveyiqtdaaidfgnaggplvnl
dgevigvntmkvtagisfaipsdrlreflhrgekknsssgisgsqrryigvmmltlspsi
laelqlrepsfpdvqhgvlihkvilgspahraglrpgdvilaigeqmvqnaedvyeavrt
qsqlavqirrgretltlyvtpevte

    Sequence, based on observed residues (ATOM records): (download) 
    >1lcyA (A:)
ppasprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadglivtnah
vvadrrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvrqgefvv
amgspfalqntitsgivssaqrpnveyiqtdaaidfgnaggplvnldgevigvntmkvta
gisfaipsdrlreflhrryigvmmltlspsilaelqlrepsfpdvqhgvlihkvilgspa
hraglrpgdvilaigeqmvqnaedvyeavrtqsqlavqirrgretltlyvtpevte