PDB entry 1hzh

View 1hzh on RCSB PDB site
Description: crystal structure of the intact human igg b12 with broad and potent activity against primary hiv-1 isolates: a template for hiv vaccine design
Class: immune system
Keywords: immunoglobulin, antibody, b12, IMMUNE SYSTEM
Deposited on 2001-01-24, released 2001-08-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: immunoglobulin heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1HZH (0-123)
    • Uniprot P0DOX5 (124-456)
      • conflict (224)
    Domains in SCOPe 2.08: d1hzhh1, d1hzhh2, d1hzhh3, d1hzhh4
  • Chain 'K':
    Compound: immunoglobulin heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1HZH (0-123)
    • Uniprot P0DOX5 (124-End)
      • conflict (224)
    Domains in SCOPe 2.08: d1hzhk1, d1hzhk2, d1hzhk3, d1hzhk4
  • Chain 'L':
    Compound: IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1HZH (0-106)
    • Uniprot Q8TCD0 (107-214)
      • conflict (202)
    Domains in SCOPe 2.08: d1hzhl1, d1hzhl2
  • Chain 'M':
    Compound: IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1HZH (0-106)
    • Uniprot Q8TCD0 (107-214)
      • conflict (202)
    Domains in SCOPe 2.08: d1hzhm1, d1hzhm2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hzhH (H:)
qvqlvqsgaevkkpgasvkvscqasgyrfsnfvihwvrqapgqrfewmgwinpyngnkef
sakfqdrvtftadtsantaymelrslrsadtavyycarvgpyswddspqdnyymdvwgkg
ttvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkaepkscdkthtcppcp
apellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktk
preeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvyt
lppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskl
tvdksrwqqgnvfscsvmhealhnhytqkslslspgk

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1hzhK (K:)
qvqlvqsgaevkkpgasvkvscqasgyrfsnfvihwvrqapgqrfewmgwinpyngnkef
sakfqdrvtftadtsantaymelrslrsadtavyycarvgpyswddspqdnyymdvwgkg
ttvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkaepkscdkthtcppcp
apellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktk
preeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvyt
lppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskl
tvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >1hzhK (K:)
qvqlvqsgaevkkpgasvkvscqasgyrfsnfvihwvrqapgqrfewmgwinpyngnkef
sakfqdrvtftadtsantaymelrslrsadtavyycarvgpyswddspqdnyymdvwgkg
ttvivssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkaepkscdkcppcpapellggpsv
flfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynsty
rvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrdeltk
nqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqg
nvfscsvmhealhnhytqkslsls

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hzhL (L:)
eivltqspgtlslspgeratfscrsshsirsrrvawyqhkpgqaprlvihgvsnrasgis
drfsgsgsgtdftltitrvepedfalyycqvygassytfgqgtklerkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglrspvtksfnrgec

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hzhM (M:)
eivltqspgtlslspgeratfscrsshsirsrrvawyqhkpgqaprlvihgvsnrasgis
drfsgsgsgtdftltitrvepedfalyycqvygassytfgqgtklerkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglrspvtksfnrgec