PDB entry 1fyr

View 1fyr on RCSB PDB site
Description: dimer formation through domain swapping in the crystal structure of the grb2-sh2 ac-pyvnv complex
Class: hormone/growth factor
Keywords: Grb2, SH2 domain, phosphopeptide, Met, domain swapping, dimerization
Deposited on 2000-10-03, released 2000-12-06
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.22
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1fyra_
  • Chain 'B':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1fyrb_
  • Chain 'C':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1fyrc_
  • Chain 'D':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1fyrd_
  • Chain 'I':
    Compound: hepatocyte growth factor receptor peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (0-3)
      • modified residue (0)
  • Chain 'J':
    Compound: hepatocyte growth factor receptor peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (0-3)
      • modified residue (0)
  • Chain 'K':
    Compound: hepatocyte growth factor receptor peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (0-3)
      • modified residue (0)
  • Chain 'L':
    Compound: hepatocyte growth factor receptor peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (0-3)
      • modified residue (0)
  • Heterogens: ACE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1fyrA (A:)
gsknyiemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqh
fkvlrdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyv

    Sequence, based on observed residues (ATOM records): (download) 
    >1fyrA (A:)
hpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdgagk
yflwvvkfnslnelvdyhrstsvsrnqqiflrdie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1fyrB (B:)
gsknyiemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqh
fkvlrdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyv

    Sequence, based on observed residues (ATOM records): (download) 
    >1fyrB (B:)
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdie

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1fyrC (C:)
gsknyiemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqh
fkvlrdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyv

    Sequence, based on observed residues (ATOM records): (download) 
    >1fyrC (C:)
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdie

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1fyrD (D:)
gsknyiemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqh
fkvlrdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyv

    Sequence, based on observed residues (ATOM records): (download) 
    >1fyrD (D:)
hpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdgagk
yflwvvkfnslnelvdyhrstsvsrnqqiflrdie

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.