PDB entry 1e0f

View 1e0f on RCSB PDB site
Description: Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor
Class: hydrolase
Keywords: coagulation/crystal structure/heparin-b, coagulation/crystal structure/heparin-binding site/ hirudin/thrombin inhibitor, hydrolase
Deposited on 2000-03-27, released 2000-11-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-05, with a file datestamp of 2017-06-30.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0f.1
  • Chain 'B':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0f.2
  • Chain 'C':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0f.3
  • Chain 'D':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-End)
      • conflict (45)
    Domains in SCOPe 2.07: d1e0f.1
  • Chain 'E':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-End)
      • conflict (45)
    Domains in SCOPe 2.07: d1e0f.2
  • Chain 'F':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-258)
      • conflict (45)
    Domains in SCOPe 2.07: d1e0f.3
  • Chain 'I':
    Compound: haemadin
    Species: HAEMADIPSA SYLVESTRIS [TaxId:13555]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0fi_
  • Chain 'J':
    Compound: haemadin
    Species: HAEMADIPSA SYLVESTRIS [TaxId:13555]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0fj_
  • Chain 'K':
    Compound: haemadin
    Species: HAEMADIPSA SYLVESTRIS [TaxId:13555]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1e0fk_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e0fA (A:)
tfgsgeadcglrplfekksledkterellesyidgr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e0fB (B:)
tfgsgeadcglrplfekksledkterellesyidgr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1e0fC (C:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1e0fC (C:)
fgsgeadcglrplfekksledkterellesyidgr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1e0fD (D:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1e0fD (D:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1e0fE (E:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1e0fE (E:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidq

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e0fF (F:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e0fI (I:)
irfgmgkvpcpdgevgytcdcgekiclygqscndgqcsgdpkpssefeefeideeek

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1e0fJ (J:)
irfgmgkvpcpdgevgytcdcgekiclygqscndgqcsgdpkpssefeefeideeek

    Sequence, based on observed residues (ATOM records): (download) 
    >1e0fJ (J:)
irfgmgkvpcpdgevgytcdcgekiclygqscndgqcsgdpkpssefeefeidee

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e0fK (K:)
irfgmgkvpcpdgevgytcdcgekiclygqscndgqcsgdpkpssefeefeideeek