PDB entry 1dx5

View 1dx5 on RCSB PDB site
Description: crystal structure of the thrombin-thrombomodulin complex
Class: hydrolase/hydrolase inhibitor
Keywords: serine proteinase, egf-like domains, anticoagulant complex, antifibrinolytic complex, hydrolase-hydrolase inhibitor complex
Deposited on 1999-12-20, released 2000-04-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-21.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.2
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Thrombin light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (8-35)
  Domains in SCOPe 2.04: d1dx5.1
• Chain 'B':
  Compound: Thrombin light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (8-35)
  Domains in SCOPe 2.04: d1dx5.2
• Chain 'C':
  Compound: Thrombin light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (8-35)
  Domains in SCOPe 2.04: d1dx5.3
• Chain 'D':
  Compound: Thrombin light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (8-35)
  Domains in SCOPe 2.04: d1dx5.4
• Chain 'E':
  Compound: thrombin inhibitor glu-gly-arg-0qe
  Database cross-references and differences (RAF-indexed):
  • PDB 1DX5 (0-3)
• Chain 'F':
  Compound: thrombin inhibitor glu-gly-arg-0qe
  Database cross-references and differences (RAF-indexed):
  • PDB 1DX5 (0-3)
• Chain 'G':
  Compound: thrombin inhibitor glu-gly-arg-0qe
  Database cross-references and differences (RAF-indexed):
  • PDB 1DX5 (0-3)
• Chain 'H':
  Compound: thrombin inhibitor glu-gly-arg-0qe
  Database cross-references and differences (RAF-indexed):
  • PDB 1DX5 (0-3)
• Chain 'I':
  Compound: thrombomodulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07204 (0-117)
    • result of deglycosyla (19)
    • engineered (111-112)
  Domains in SCOPe 2.04: d1dx5i1, d1dx5i2, d1dx5i3
• Chain 'J':
  Compound: thrombomodulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07204 (0-117)
    • result of deglycosyla (19)
    • engineered (111-112)
  Domains in SCOPe 2.04: d1dx5j1, d1dx5j2, d1dx5j3
• Chain 'K':
  Compound: thrombomodulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07204 (0-117)
    • result of deglycosyla (19)
    • engineered (111-112)
  Domains in SCOPe 2.04: d1dx5k1, d1dx5k2, d1dx5k3
• Chain 'L':
  Compound: thrombomodulin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07204 (0-117)
    • result of deglycosyla (19)
    • engineered (111-112)
  Domains in SCOPe 2.04: d1dx5l1, d1dx5l2, d1dx5l3
• Chain 'M':
  Compound: Thrombin heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (0-258)
    • conflict (45)
  Domains in SCOPe 2.04: d1dx5.1
• Chain 'N':
  Compound: Thrombin heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (0-258)
    • conflict (45)
  Domains in SCOPe 2.04: d1dx5.2
• Chain 'O':
  Compound: Thrombin heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (0-258)
    • conflict (45)
  Domains in SCOPe 2.04: d1dx5.3
• Chain 'P':
  Compound: Thrombin heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (0-258)
    • conflict (45)
  Domains in SCOPe 2.04: d1dx5.4
• Heterogens: FMT, CA, NA, NDG, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5A (A:)
  tfgsgeadcglrplfekksledkterellesyidgr
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5B (B:)
  tfgsgeadcglrplfekksledkterellesyidgr
  

  
  
• Chain 'C':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5C (C:)
  tfgsgeadcglrplfekksledkterellesyidgr
  

  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5D (D:)
  tfgsgeadcglrplfekksledkterellesyidgr
  

  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5I (I:)
  vepvdpcfranceyqcqpldqtsylcvcaegfapiphephrcqmfcnqtacpadcdpntq
  ascecpegyilddgfictdidecenggfcsgvchnlpgtfecicgpdsalagqigtdc
  

  
  
• Chain 'J':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5J (J:)
  vepvdpcfranceyqcqpldqtsylcvcaegfapiphephrcqmfcnqtacpadcdpntq
  ascecpegyilddgfictdidecenggfcsgvchnlpgtfecicgpdsalagqigtdc
  

  
  
• Chain 'K':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5K (K:)
  vepvdpcfranceyqcqpldqtsylcvcaegfapiphephrcqmfcnqtacpadcdpntq
  ascecpegyilddgfictdidecenggfcsgvchnlpgtfecicgpdsalagqigtdc
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5L (L:)
  vepvdpcfranceyqcqpldqtsylcvcaegfapiphephrcqmfcnqtacpadcdpntq
  ascecpegyilddgfictdidecenggfcsgvchnlpgtfecicgpdsalagqigtdc
  

  
  
• Chain 'M':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5M (M:)
  ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
  vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
  pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
  itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
  thvfrlkkwiqkvidqfge
  

  
  
• Chain 'N':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5N (N:)
  ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
  vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
  pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
  itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
  thvfrlkkwiqkvidqfge
  

  
  
• Chain 'O':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5O (O:)
  ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
  vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
  pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
  itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
  thvfrlkkwiqkvidqfge
  

  
  
• Chain 'P':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dx5P (P:)
  ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknfiendll
  vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
  pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
  itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
  thvfrlkkwiqkvidqfge