PDB entry 1bi8

View 1bi8 on RCSB PDB site
Description: mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex
Class: complex (kinase/inhibitor)
Keywords: cyclin dependent kinase, cyclin dependent kinase inhibitory protein, cdk, ink4, cell cycle, complex (kinase/inhibitor)
Deposited on 1998-06-22, released 1999-01-13
The last revision prior to the SCOP 1.75 freeze date was dated 1999-02-16, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.255
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 6
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1bi8a_
  • Chain 'B':
    Compound: cyclin-dependent kinase inhibitor
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1bi8b_
  • Chain 'C':
    Compound: cyclin-dependent kinase 6
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1bi8c_
  • Chain 'D':
    Compound: cyclin-dependent kinase inhibitor
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1bi8d_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1bi8A (A:)
mekdglcradqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstir
evavlrhletfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvpte
tikdmmfqllrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvv
vtlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpge
edwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyf
qdlerckenldshlppsqntselnta

    Sequence, based on observed residues (ATOM records): (download) 
    >1bi8A (A:)
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqehpnvvrlfdvctvsrtkltlv
fehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqnilvtssg
qikladfglariysfqmaltsvvvtlwyrapevllqssyatpvdlwsvgcifaemfrrkp
lfrgssdvdqlgkildviglpgeedwprdvalprqafhsksaqpiekfvtdidelgkdll
lkcltfnpakrisaysalshpyfq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1bi8B (B:)
mlleevragdrlsgaaargdvqevrrllhrelvhpdalnrfgktalqvmmfgstaialel
lkqgaspnvqdtsgtspvhdaartgfldtlkvlvehgadvnvpdgtgalpihlavqeght
avvsflaaesdlhrrdargltplelalqrgaqdlvdilqghmvapl

    Sequence, based on observed residues (ATOM records): (download) 
    >1bi8B (B:)
vragdrlsgaaargdvqevrrllhrelvhpdalnrfgktalqvmmfgstaialellkqga
spnvqdtsgtspvhdaartgfldtlkvlvehgadvnvpdgtgalpihlavqeghtavvsf
laaesdlhrrdargltplelalqrgaqdlvdilqg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1bi8C (C:)
mekdglcradqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstir
evavlrhletfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvpte
tikdmmfqllrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvv
vtlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpge
edwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyf
qdlerckenldshlppsqntselnta

    Sequence, based on observed residues (ATOM records): (download) 
    >1bi8C (C:)
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqehpnvvrlfdvctvsrtkltlv
fehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqnilvtssg
qikladfglariysfqmaltsvvvtlwyrapevllqssyatpvdlwsvgcifaemfrrkp
lfrgssdvdqlgkildviglpgeedwprdvalprqafhsksaqpiekfvtdidelgkdll
lkcltfnpakrisaysalshpyfq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1bi8D (D:)
mlleevragdrlsgaaargdvqevrrllhrelvhpdalnrfgktalqvmmfgstaialel
lkqgaspnvqdtsgtspvhdaartgfldtlkvlvehgadvnvpdgtgalpihlavqeght
avvsflaaesdlhrrdargltplelalqrgaqdlvdilqghmvapl

    Sequence, based on observed residues (ATOM records): (download) 
    >1bi8D (D:)
vragdrlsgaaargdvqevrrllhrelvhpdalnrfgktalqvmmfgstaialellkqga
spnvqdtsgtspvhdaartgfldtlkvlvehgadvnvpdgtgalpihlavqeghtavvsf
laaesdlhrrdargltplelalqrgaqdlvdilqg