SCOPe 2.04: Domain d1s3wa_: 1s3w A:

Lineage for d1s3wa_ (1s3w A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d1s3wa_: 1s3w A: [98466]
   complexed with nap, tqt

Details for d1s3wa_

PDB Entry: 1s3w, 1.9 Å

PDB Description: Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1s3wa_:

Sequence; same for both SEQRES and ATOM records:

>d1s3wa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d1s3wa_:

• d1s3wa_ first appeared in SCOP 1.67
  
• d1s3wa_ appears in SCOPe 2.03
  
• d1s3wa_ appears in SCOPe 2.05
  
• d1s3wa_ appears in the current release, SCOPe 2.08