SCOP 1.67: Domain d1rg2b2: 1rg2 B:351-608

Lineage for d1rg2b2 (1rg2 B:351-608)

1. Root: SCOP 1.67

2. Class d: Alpha and beta proteins (a+b) [53931] (260 folds)

3. Fold d.136: Phospholipase D/nuclease [56023] (1 superfamily)
   beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234

4. Superfamily d.136.1: Phospholipase D/nuclease [56024] (3 families)

5. Family d.136.1.3: Tyrosyl-DNA phosphodiesterase TDP1 [69815] (1 protein)

6. Protein Tyrosyl-DNA phosphodiesterase TDP1 [69816] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69817] (12 PDB entries)

8. Domain d1rg2b2: 1rg2 B:351-608 [97422]
   complexed with otr, ots, spm, vo4; mutant

Details for d1rg2b2

PDB Entry: 1rg2, 2.1 Å

PDB Description: crystal structure of human tyrosyl-dna phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide agta

SCOP Domain Sequences for d1rg2b2:

Sequence, based on SEQRES records:

>d1rg2b2 d.136.1.3 (B:351-608) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens)}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssvgslgadesk
wlcsefkesmltlgkesktpgkssvplyliypsvenvrtslegypaggslpysiqtaekq
nwlhsyfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngt
qlmirsyelgvlflpsalgldsfkvkqkffagsqepmatfpvpydlppelygskdrpwiw
nipyvkapdthgnmwvps

Sequence, based on observed residues (ATOM records):

>d1rg2b2 d.136.1.3 (B:351-608) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens)}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssvgslgadesk
wlcsefkesmltlgsvplyliypsvenvrtslegypaggslpysiqtaekqnwlhsyfhk
wsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngtqlmirsyel
gvlflpsalgldsfkvkqkfmatfpvpydlppelygskdrpwiwnipyvkapdthgnmwv
ps

Timeline for d1rg2b2:

• d1rg2b2 is new in SCOP 1.67
  
• d1rg2b2 appears in SCOP 1.69
  
• d1rg2b2 appears in the current release, SCOPe 2.08