SCOP 1.75: Domain d1r3ih1: 1r3i H:1-118

Lineage for d1r3ih1 (1r3i H:1-118)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (152 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E
   SQ NA # humanized antibody
   Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01750 20-116 #
   HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1r3ih1: 1r3i H:1-118 [96924]
   Other proteins in same PDB: d1r3ic_, d1r3ih2, d1r3il1, d1r3il2
   part of Fab against potassium channel KcsA
   complexed with dga, f09, rb; mutant

Details for d1r3ih1

PDB Entry: 1r3i, 2.4 Å

PDB Description: potassium channel kcsa-fab complex in rb+

PDB Compounds: (H:) antibody fab fragment heavy chain

SCOP Domain Sequences for d1r3ih1:

Sequence; same for both SEQRES and ATOM records:

>d1r3ih1 b.1.1.1 (H:1-118) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qvqlqqpgaelvkpgasvklsckasgytftsdwihwvkqrpghglewigeiipsygrany
nekiqkkatltadkssstafmqlssltsedsavyycarergdgyfavwgagttvtvss

Timeline for d1r3ih1:

• d1r3ih1 first appeared in SCOP 1.67
  
• d1r3ih1 appears in SCOP 1.73
  
• d1r3ih1 appears in SCOPe 2.01
  
• d1r3ih1 appears in the current release, SCOPe 2.08